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PubMed COVID-19 Clinical Care

2791 - 2800 of 6928 results found

AntiRef: reference clusters of human antibody sequences

Date
Friday, October 27, 2023 - 4:00 AM
Description
MOTIVATION: Genetic biases in the human antibody repertoire result in publicly available antibody sequence datasets that contain many duplicate or highly similar sequences. Available datasets are further skewed by the predominance of studies focused

An Update on the Current State of SARS-CoV-2 Mac1 Inhibitors

Date
Friday, October 27, 2023 - 4:00 AM
Description
Non-structural protein 3 (nsp3) from all coronaviruses (CoVs) contains a conserved macrodomain, known as Mac1, that has been proposed as a potential therapeutic target for CoVs due to its critical role in viral pathogenesis. Mac1 is an ADP-ribose